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Wednesday, May 6, 2020 | History

2 edition of pharmacokinetics and pharmacodynamics of 9-aminocamptothecin against human cancer found in the catalog.

pharmacokinetics and pharmacodynamics of 9-aminocamptothecin against human cancer

Meili Li

pharmacokinetics and pharmacodynamics of 9-aminocamptothecin against human cancer

by Meili Li

  • 206 Want to read
  • 29 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 92 leaves
Number of Pages92
ID Numbers
Open LibraryOL19012945M

The book starts with chapters that cover general drug delivery issues such as physicochemical and biological barriers, various pathways for drug delivery, for- mulation, pharmacokinetic and pharmacodynamic issues, metabolism, and cell cul- ture models used in studying drug delivery. Identification Name 9-aminocamptothecin Accession Number DB Type Small Molecule Groups Investigational Description. Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal .

Full text of "Annual report: National Cancer Institute (U.S.)" See other formats. The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to mustard-based alkylating agents such as uracil mustard and analogs, derivatives, or Author: 丹尼斯M布朗.

Targeted delivery combined with controlled drug release has a pivotal role in the future of personalized medicine. This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways.   Novel phosphonic acid based prodrugs of PMEA and its analogues of the (R)-Enantiomers of 9-(2-Phosphonylmethoxypropyl)-Adenine and 9-(2-Phosphonylmethoxypropyl)-2,6-diamiopurine against Human Immunodeficiency Virus in Different Human Cell Systems” Biochem. and Biophys. “Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of.


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Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin against human cancer by Meili Li Download PDF EPUB FB2

Thirty‐two patients with cancer received oral 9‐aminocamptothecin formulated in capsules with polyethylene glycol– as excipient at doses that ranged from to mg/m 2 /day.

Serial plasma pharmacokinetics and pharmacodynamics of 9-aminocamptothecin against human cancer book saliva samples were obtained on days 1 and 6 or days 1 and 8 of the first cycle and analyzed for the lactone and carboxylate forms of 9 Cited by: Abstract.

In preclinical studies first published in by Giovanella and colleagues, 9-aminocamptothecin (9-AC) demonstrated highly promising antitumor activity against human colorectal cancer xenografts ().This led to an extensive drug development program for 9-AC initially under the guidance of the National Cancer Institute, and later in cooperation with pharmaceutical industry : Chris H.

Takimoto. A water soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer–9-aminocamptothecin (9-AC) conjugate was designed for oral colon-specific drug delivery in the treatment of colon ative studies between the polymer conjugate and free drug have been performed to assess their biodistribution and pharmacokinetics in by: To investigate the pharmacokinetics and pharmacodynamics of 9-aminocamptothecin (9-AC) infused over 72 hours at doses of 5 to 74 micrograms/m2/h.

9-AC lactone and total (lactone plus carboxylate Author: Chris H Takimoto. Maier-Salamon A, Thalhammer T, Reznicek G, Bohmdorfer M, Zupko I, Hartl A, Jaeger W: Cytochrome P 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. Aug;45(2) doi: /ijo Epub May [PMID].

In this review the clinical pharmacokinetics of camptothecin topoisomerase I inhibitors, an important new class of anticancer drugs, is discussed. Two prototypes, topotecan and irinotecan, are currently marketed in many European countries and the USA for the treatment of patients with ovarian and colorectal cancer, respectively.

Other camptothecin derivatives, including lurtotecan, 9 Cited by: In this review the clinical pharmacokinetics of camptothecin topoisomerase I inhibitors, an important new class of anticancer drugs, is discussed. Two prototypes, topotecan and irinotecan, are currently marketed in many European countries and the USA for the treatment of Cited by: The camptothecins provide a novel class of effective anticancer agents that exert their action against DNA topoisomerase I.

Members of the camptothecins include topotecan, irinotecan, 9-aminocamptothecin, and 9-nitrocamptothecin, which are analogs of the plant alkaloid 20(S) by:   We examined the toxicity and anti-tumour activity of 9-aminocamptothecin glucuronide, a new glucuronide prodrug of 9-aminocamptothecin, to evaluate its potential clinical utility.

9-aminocamptothecin glucuronide was 25–60 times less toxic than 9-aminocamptothecin to five human cancer cell lines. β-glucuronidase activated 9-aminocamptothecin Cited by:   9-Nitrocamptothecin has completed phase III studies in patients with newly diagnosed and refractory pancreatic cancer; however, the optimal 9-nitrocamptothecin treatment regimen is unclear.

We used an intermittent schedule of 9-nitrocamptothecin to evaluate the relationship between plasma exposure of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite and antitumor response in Cited by: 9.

Multicenter Study of 9-Aminocamptothecin (9-AC) in Patients With Refractory Leukemia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S. Federal Government. The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer.

Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. Pharmacokinetics of the 9-Amino Methylenedioxy Derivatives of Camptothecin in Mice Article (PDF Available) in Cancer Research 53(13) August with 37 Reads How we measure.

Rubitecan is an effective drug against pancreatic cancer and other solid tumors. One major problem is the lack of oral bioavailability due to low permeability and poor water solubility.

One study shows 9-NC-SD through Soluplus1-based solid dispersion system is a Routes of administration: Oral (capsules). Know about technical details of 9-Aminocamptothecin like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at en Bond Acceptor Count: 6.

Introduction. Colorectal cancer is the second most common cause of cancer mortality in the United States. It has been estimated thatnew cases will be diagnosed in [].Colorectal cancer can be cured in the early stages and in selected patients with advanced disease by definitive resection, however, chemotherapy for advanced and metastatic disease remains by: Following a single oral dose of mg/kg of 9NC, the maximum concentration of 9NC in the human volunteer was ng/ml at h with an AUC of ngh/ml and a half-life of h.

In this human, the Cmax of 9AC was ng/ml at h; the AUC was Cited by: BACKGROUND. 9-Aminocamptothecin (9AC) and its parent compound, camptothecin, have shown outstanding preclinical activity against colorectal carcinoma.

Irinotecan (CPT), another camptothecin derivative, has demonstrated clinical activity in patients with 5-fluorouracil (5-FU)- refractory colorectal carcinoma. by: The rs SNP in ABCC1 have a significant impact on the pharmacokinetics and pharmacodynamics of irinotecan in advanced cancer patients.

Severe neurotoxicity has been significantly associated with ABCC1 SNP rs in colorectal cancer patients treated with adjuvant FOLFOX4 (5-fluorouracil, leucovorin and oxaliplatin) regimen [ ].Cited by: Phase I and pharmacologic study of 9-aminocamptothecin colloidal dispersion formulation in patients with refractory or relapsed acute leukemia.

and myelodysplastic syndrome. In this phase 1 study, we investigated the toxicity profile, pharmacokinetics, and activity of a prolonged continuous infusion schedule of the colloidal dispersion Cited by:.

Pharmacokinetics and Pharmacodynamics. Pharmacokinetics could be evaluated in 18 patients, 1 each at the and mg/day dose levels and 2 at the mg/day dose level being inevaluable. Mean plasma levels (±SD) for BN (closed ring) and BN (open ring) at each i.v. and oral dose level are shown in Figs. 2 ⇓ and 3 ⇓, respectively.Purpose To determine the maximum-tolerated dose (MTD), toxicities, and clinical effect of tipifarnib, a farnesyltransferase (FTase) inhibitor, in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs (EIAEDs).

This study compares the pharmacokinetics and pharmacodynamics of tipifarnib at MTD in patients on and off EIAEDs. Patients and Methods Recurrent malignant Cited by: Pharmacodynamics and pharmacokinetics of a hour infusion of 9-aminocamptothecin in adult cancer patients. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology.

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